Post-Doc Research Associate - Brouwer Lab
University of North Carolina at Chapel Hill

Department:

SOP-DPET - 452200

04/22/2022

Yes

Postdoctoral Scholar

Post-Doc Research Associate - Brouwer Lab

PDS003449

Full-Time Temporary

40

1

Chapel Hill, NC

North Carolina, US

$53,760 - $55,000

12 Months

The UNC Eshelman School of Pharmacy (www.pharmacy.unc.edu) is one of five health science schools (Pharmacy, Nursing, Dentistry, Public Health, Medicine) at the University of North Carolina at Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students and 145 graduate students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting-edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School's Strategic Plan (https://pharmacy.unc.edu/about/oe/strategic-plan/).

Our Vision is to be the global leader in pharmacy and pharmaceutical sciences. Our Mission is to prepare leaders and innovators to solve the world's most pressing health care challenges. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.

A postdoctoral research position is available immediately to investigate the utility of in vitro models (e.g., hepatic organoid 3D cell models, sandwich-cultured hepatocytes, HuH-7 cells, membrane vesicle systems) to (1) predict the hepatic disposition of drugs and metabolites in vivo, (2) predict the impact of disease-mediated alterations in transport function on hepatocellular accumulation and routes of excretion (canalicular vs. basolateral) of anionic drugs/metabolites, and (3) examine hepatic transporter trafficking and regulatory mechanisms.

NIH-funded research program to study the hepatic disposition of xenobiotics utilizing in vitro model systems, regulation/trafficking of transport proteins, and cellular/molecular mechanisms responsible for hepatic structure and function. Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS, maintaining the laboratory's animal care and use and radiation safety records in accordance with institutional, state, and federal guidelines.

Ph.D. in cell/molecular biology, biochemistry, pharmacology, pharmaceutics, engineering or related discipline.

Experience with cell culture and advanced molecular biology/biochemistry techniques. Excellent communication skills and ability to work independently as well as a member of an interdisciplinary team are essential.

Preference will be given to candidates with expertise in pharmacokinetic modeling and simulation, and drug-induced liver injury.

Position will require some night and weekend bench and manuscript work. Position includes exposure to lab animals, human hepatocytes, adenoviral vector, and radiolabeled BSL-2 compounds.

For information on UNC Postdoctoral Benefits and Services click here