Oral Bioavailability Enhancement Co-op, Synthetic Product Development
Alexion

This is what you will do:

Alexion's Product Development and Clinical Supply (PDCS) organization is seeking an undergraduate or master student working towards a degree in pharmaceutical sciences, chemical engineering or equivalent discipline for a 6 months Co-op during the 1st half of 2025 with the Synthetic Product Development (SPD) Team.

This cross-functional team consists of scientific and technical professionals tasked to deliver process and product development solutions for synthetic drug substances and oral solid dosage drug products within Alexion's portfolio, spanning preclinical development through commercial launch. You will learn and apply skills related to the development and characterization of oral bioavailability enhancement formulations and the equipment and technologies needed for the development.

You will be responsible for:

Working with scientists and engineers to support the development and characterization of oral bioavailability enhancement formulations. Activities may include:

• Engage with the latest laboratory technologies being introduced in our new laboratories at 101 College Street.
• Conduct hands-on development and in vitro characterization of advanced oral bioavailability enhancement formulations (e.g., spray-dried dispersion, oral lipid formulation) to solve oral drug delivery challenges
• Conduct in silico modeling (e.g., Gastroplus) to predict the impact of formulation on oral absorption
• Effectively communicate scientific challenges and the technical approaches used to address them, showcasing strong presentation skills.

Requirements:

• Educational Background: Currently enrolled in a BS/MS program in Pharmaceutical Sciences, Chemical Engineering, or a related field.
• Technical Skills: Basic understanding of pharmaceutical processes and laboratory practices. Prior lab experience is a plus.
• Analytical Thinking: Strong analytical and problem-solving skills, with an ability to think critically about experimental design and data interpretation.
• Communication Skills: Effective written and verbal communication skills. Ability to present complex information clearly and concisely.
• Teamwork and Collaboration: Willingness to work collaboratively in a team environment and contribute to team goals.
• Adaptability: Ability to adapt to new challenges and a fast-paced working environment.
• Initiative: Self-motivated with a strong desire to learn and contribute.
• Availability: Must be available during the full 6 months term and maintain general availability during standard business hours.

• Preferred but not required experience:
  • Experience in spray-dried dispersion and oral lipid formulation
  • Experience in in vitro characterization tools, such as Pion system
  • In-depth understanding of oral absorption and in silico modeling

• The duties of this role are generally conducted in both an office and laboratory environment.
  • As is typical of an office-based role, you must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
  • The duties of this role are also conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/de-gown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

Date Posted
21-Oct-2024

Closing Date
27-Oct-2024Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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